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Rajam S Mani Selected Research

Polynucleotide 5'-Hydroxyl-Kinase (Kinase, Polynucleotide)

10/2021A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3'-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer.
1/2017The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair.
11/2011Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.

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Rajam S Mani Research Topics

Disease

5Neoplasms (Cancer)
01/2022 - 11/2019
3Colorectal Neoplasms (Colorectal Cancer)
10/2021 - 12/2019
1Microcephaly
01/2017
1Seizures (Absence Seizure)
01/2017
1autosomal recessive 1 Spinocerebellar ataxia
01/2017
1Ataxia Telangiectasia (Louis Bar Syndrome)
11/2011
1Lung Neoplasms (Lung Cancer)
01/2010

Drug/Important Bio-Agent (IBA)

3Cyclophosphamide (Cytoxan)FDA LinkGeneric
01/2022 - 12/2019
3Polynucleotide 5'-Hydroxyl-Kinase (Kinase, Polynucleotide)IBA
10/2021 - 11/2011
3Phosphoric Monoester Hydrolases (Phosphatases)IBA
10/2021 - 11/2011
3DNA (Deoxyribonucleic Acid)IBA
11/2019 - 11/2011
2EndonucleasesIBA
01/2022 - 10/2020
2Proteins (Proteins, Gene)FDA Link
10/2021 - 11/2019
1cremophor ELIBA
10/2021
1TensinsIBA
10/2021
1Ethanol (Ethyl Alcohol)IBA
10/2021
1Pharmaceutical PreparationsIBA
10/2021
1Excipients (Suspending Agents)IBA
10/2021
1Glucose (Dextrose)FDA LinkGeneric
10/2021
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
10/2021
1A-Form DNA (A-DNA)IBA
10/2021
1PlatinumIBA
12/2019
1DNA-Activated Protein KinaseIBA
11/2011
1Small Interfering RNA (siRNA)IBA
01/2010
1Type I DNA Topoisomerases (Topoisomerase I)IBA
01/2010
1Etoposide (VP 16)FDA LinkGeneric
01/2010
1CamptothecinIBA
01/2010
1PoisonsIBA
01/2010
1Type II DNA Topoisomerases (Topoisomerase II)IBA
01/2010
12- (1- hydroxyundecyl)- 1- (4- nitrophenylamino)- 6- phenyl- 6,7a- dihydro- 1H- pyrrolo(3,4- b)pyridine- 5,7(2H,4aH)- dioneIBA
01/2010

Therapy/Procedure

1Therapeutics
10/2021